人表皮生长因子受体2（HER2）生物标志物的免疫组织化学（IHC）染色在乳腺组织分析，临床前研究和诊断决策中广泛实践，指导癌症治疗和发病机制调查。 HER2染色需要由组织医学表演表演的艰苦组织处理和化学处理，这通常需要一天，以便在实验室中准备，增加分析时间和相关成本。在这里，我们描述了一种基于深度学习的虚拟HER2 IHC染色方法，其使用条件生成的对抗网络培训，训练以便将未标记/标记的乳房组织部分的自发荧光显微镜图像快速转化为明亮场当量的显微镜图像，匹配标准HER2 IHC染色在相同的组织部分上进行化学进行。通过定量分析证明了这一虚拟HER2染色框架的功效，其中三个董事会认证的乳房病理学家盲目地评级了HER2的几乎染色和免疫化化学染色的HER2整个幻灯片图像（WSIS），揭示了通过检查虚拟来确定的HER2分数IHC图像与其免疫组织化学染色的同类一样准确。通过相同的诊断师进行的第二种定量盲化研究进一步揭示了几乎染色的HER2图像在核细节，膜清晰度和染色伪像相对于其免疫组织化学染色的对应物的染色伪影等级具有相当的染色质量。这种虚拟HER2染色框架在实验室中绕过了昂贵，费力，耗时耗时的IHC染色程序，并且可以扩展到其他类型的生物标志物，以加速生命科学和生物医学工作流程的IHC组织染色。

Blind image quality assessment (BIQA) remains challenging due to the diversity of distortion and image content variation, which complicate the distortion patterns crossing different scales and aggravate the difficulty of the regression problem for BIQA. However, existing BIQA methods often fail to consider multi-scale distortion patterns and image content, and little research has been done on learning strategies to make the regression model produce better performance. In this paper, we propose a simple yet effective Progressive Multi-Task Image Quality Assessment (PMT-IQA) model, which contains a multi-scale feature extraction module (MS) and a progressive multi-task learning module (PMT), to help the model learn complex distortion patterns and better optimize the regression issue to align with the law of human learning process from easy to hard. To verify the effectiveness of the proposed PMT-IQA model, we conduct experiments on four widely used public datasets, and the experimental results indicate that the performance of PMT-IQA is superior to the comparison approaches, and both MS and PMT modules improve the model's performance.

In the scenario of black-box adversarial attack, the target model's parameters are unknown, and the attacker aims to find a successful adversarial perturbation based on query feedback under a query budget. Due to the limited feedback information, existing query-based black-box attack methods often require many queries for attacking each benign example. To reduce query cost, we propose to utilize the feedback information across historical attacks, dubbed example-level adversarial transferability. Specifically, by treating the attack on each benign example as one task, we develop a meta-learning framework by training a meta-generator to produce perturbations conditioned on benign examples. When attacking a new benign example, the meta generator can be quickly fine-tuned based on the feedback information of the new task as well as a few historical attacks to produce effective perturbations. Moreover, since the meta-train procedure consumes many queries to learn a generalizable generator, we utilize model-level adversarial transferability to train the meta-generator on a white-box surrogate model, then transfer it to help the attack against the target model. The proposed framework with the two types of adversarial transferability can be naturally combined with any off-the-shelf query-based attack methods to boost their performance, which is verified by extensive experiments.

Creating an essay based on a few given topics is a challenging NLP task. Although several effective methods for this problem, topic-to-essay generation, have appeared recently, there is still much room for improvement, especially in terms of the coverage of the given topics and the coherence of the generated text. In this paper, we propose a novel approach called TegFormer which utilizes the Transformer architecture where the encoder is enriched with domain-specific contexts while the decoder is enhanced by a large-scale pre-trained language model. Specifically, a \emph{Topic-Extension} layer capturing the interaction between the given topics and their domain-specific contexts is plugged into the encoder. Since the given topics are usually concise and sparse, such an additional layer can bring more topic-related semantics in to facilitate the subsequent natural language generation. Moreover, an \emph{Embedding-Fusion} module that combines the domain-specific word embeddings learnt from the given corpus and the general-purpose word embeddings provided by a GPT-2 model pre-trained on massive text data is integrated into the decoder. Since GPT-2 is at a much larger scale, it contains a lot more implicit linguistic knowledge which would help the decoder to produce more grammatical and readable text. Extensive experiments have shown that the pieces of text generated by TegFormer have better topic coverage and higher text coherence than those from SOTA topic-to-essay techniques, according to automatic and human evaluations. As revealed by ablation studies, both the Topic-Extension layer and the Embedding-Fusion module contribute substantially to TegFormer's performance advantage.

Referring image segmentation aims to segment the target object described by a given natural language expression. Typically, referring expressions contain complex relationships between the target and its surrounding objects. The main challenge of this task is to understand the visual and linguistic content simultaneously and to find the referred object accurately among all instances in the image. Currently, the most effective way to solve the above problem is to obtain aligned multi-modal features by computing the correlation between visual and linguistic feature modalities under the supervision of the ground-truth mask. However, existing paradigms have difficulty in thoroughly understanding visual and linguistic content due to the inability to perceive information directly about surrounding objects that refer to the target. This prevents them from learning aligned multi-modal features, which leads to inaccurate segmentation. To address this issue, we present a position-aware contrastive alignment network (PCAN) to enhance the alignment of multi-modal features by guiding the interaction between vision and language through prior position information. Our PCAN consists of two modules: 1) Position Aware Module (PAM), which provides position information of all objects related to natural language descriptions, and 2) Contrastive Language Understanding Module (CLUM), which enhances multi-modal alignment by comparing the features of the referred object with those of related objects. Extensive experiments on three benchmarks demonstrate our PCAN performs favorably against the state-of-the-art methods. Our code will be made publicly available.

Most deep-learning-based continuous sign language recognition (CSLR) models share a similar backbone consisting of a visual module, a sequential module, and an alignment module. However, due to limited training samples, a connectionist temporal classification loss may not train such CSLR backbones sufficiently. In this work, we propose three auxiliary tasks to enhance the CSLR backbones. The first task enhances the visual module, which is sensitive to the insufficient training problem, from the perspective of consistency. Specifically, since the information of sign languages is mainly included in signers' facial expressions and hand movements, a keypoint-guided spatial attention module is developed to enforce the visual module to focus on informative regions, i.e., spatial attention consistency. Second, noticing that both the output features of the visual and sequential modules represent the same sentence, to better exploit the backbone's power, a sentence embedding consistency constraint is imposed between the visual and sequential modules to enhance the representation power of both features. We name the CSLR model trained with the above auxiliary tasks as consistency-enhanced CSLR, which performs well on signer-dependent datasets in which all signers appear during both training and testing. To make it more robust for the signer-independent setting, a signer removal module based on feature disentanglement is further proposed to remove signer information from the backbone. Extensive ablation studies are conducted to validate the effectiveness of these auxiliary tasks. More remarkably, with a transformer-based backbone, our model achieves state-of-the-art or competitive performance on five benchmarks, PHOENIX-2014, PHOENIX-2014-T, PHOENIX-2014-SI, CSL, and CSL-Daily.

Transformer models have achieved superior performance in various natural language processing tasks. However, the quadratic computational cost of the attention mechanism limits its practicality for long sequences. There are existing attention variants that improve the computational efficiency, but they have limited ability to effectively compute global information. In parallel to Transformer models, state space models (SSMs) are tailored for long sequences, but they are not flexible enough to capture complicated local information. We propose SPADE, short for $\underline{\textbf{S}}$tate s$\underline{\textbf{P}}$ace $\underline{\textbf{A}}$ugmente$\underline{\textbf{D}}$ Transform$\underline{\textbf{E}}$r. Specifically, we augment a SSM into the bottom layer of SPADE, and we employ efficient local attention methods for the other layers. The SSM augments global information, which complements the lack of long-range dependency issue in local attention methods. Experimental results on the Long Range Arena benchmark and language modeling tasks demonstrate the effectiveness of the proposed method. To further demonstrate the scalability of SPADE, we pre-train large encoder-decoder models and present fine-tuning results on natural language understanding and natural language generation tasks.

Human modeling and relighting are two fundamental problems in computer vision and graphics, where high-quality datasets can largely facilitate related research. However, most existing human datasets only provide multi-view human images captured under the same illumination. Although valuable for modeling tasks, they are not readily used in relighting problems. To promote research in both fields, in this paper, we present UltraStage, a new 3D human dataset that contains more than 2K high-quality human assets captured under both multi-view and multi-illumination settings. Specifically, for each example, we provide 32 surrounding views illuminated with one white light and two gradient illuminations. In addition to regular multi-view images, gradient illuminations help recover detailed surface normal and spatially-varying material maps, enabling various relighting applications. Inspired by recent advances in neural representation, we further interpret each example into a neural human asset which allows novel view synthesis under arbitrary lighting conditions. We show our neural human assets can achieve extremely high capture performance and are capable of representing fine details such as facial wrinkles and cloth folds. We also validate UltraStage in single image relighting tasks, training neural networks with virtual relighted data from neural assets and demonstrating realistic rendering improvements over prior arts. UltraStage will be publicly available to the community to stimulate significant future developments in various human modeling and rendering tasks.

Humans constantly interact with objects in daily life tasks. Capturing such processes and subsequently conducting visual inferences from a fixed viewpoint suffers from occlusions, shape and texture ambiguities, motions, etc. To mitigate the problem, it is essential to build a training dataset that captures free-viewpoint interactions. We construct a dense multi-view dome to acquire a complex human object interaction dataset, named HODome, that consists of $\sim$75M frames on 10 subjects interacting with 23 objects. To process the HODome dataset, we develop NeuralDome, a layer-wise neural processing pipeline tailored for multi-view video inputs to conduct accurate tracking, geometry reconstruction and free-view rendering, for both human subjects and objects. Extensive experiments on the HODome dataset demonstrate the effectiveness of NeuralDome on a variety of inference, modeling, and rendering tasks. Both the dataset and the NeuralDome tools will be disseminated to the community for further development.

Accurate traffic flow prediction, a hotspot for intelligent transportation research, is the prerequisite for mastering traffic and making travel plans. The speed of traffic flow can be affected by roads condition, weather, holidays, etc. Furthermore, the sensors to catch the information about traffic flow will be interfered with by environmental factors such as illumination, collection time, occlusion, etc. Therefore, the traffic flow in the practical transportation system is complicated, uncertain, and challenging to predict accurately. This paper proposes a deep encoder-decoder prediction framework based on variational Bayesian inference. A Bayesian neural network is constructed by combining variational inference with gated recurrent units (GRU) and used as the deep neural network unit of the encoder-decoder framework to mine the intrinsic dynamics of traffic flow. Then, the variational inference is introduced into the multi-head attention mechanism to avoid noise-induced deterioration of prediction accuracy. The proposed model achieves superior prediction performance on the Guangzhou urban traffic flow dataset over the benchmarks, particularly when the long-term prediction.